Sickle Cell Disease
Chronic SAD/SCD Shows Ineffective Erythropoiesis
Published in Blood Weekly, September 13th, 1999
Marie-Jose Blouin and colleagues of Canada's Institut de Recherches Cliniques de Montreal, investigated the mechanisms of sickle cell disease (SCD) hematopoietic/erythropoietic defects in a murine model ("Altered Hematopoiesis in Murine Sickle Cell Disease," Blood, August 15, 1999;94(4):1451-1459).
The researchers used bone marrow, spleen, and/or peripheral blood from the transgenic SAD mouse model, which closely reproduces the biochemical and physiological disorders found in human SCD.
In the...
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Source: Blood Weekly (1999-09-13)
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