Published in Blood Weekly, September 13th, 1999
Numerous studies have shown the essential role of angiogenesis for successful osteogenesis during endochondral ossification and fracture repair. Vascular endothelial growth factor (VEGF), a potent endothelial cell-specific cytokine, has been shown to be mitogenic and chemotactic for endothelial cells in vitro and angiogenic in many in vivo models, noted D.S. Steinbrech and colleagues from New York University Medical Center.
Based on previous work demonstrating that (1) VEGF is up-regulated during membranous fracture...
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