Malaria (Pathology)

Cerebral Malaria Affects Blood-Brain Barrier

Published in Blood Weekly, September 27th, 1999

Functional changes to the blood-brain barrier occur in cerebral malaria.

Patients infected with the malaria parasite Plasmodium falciparum may develop a diffuse reversible encephalopathy, termed cerebral malaria.

"It is unclear how the intraerythrocytic parasite, which sequesters in the cerebral microvasculature but does not enter the brain parenchyma, induces this neurological syndrome," H. Brown and colleagues from the United Kingdom's Oxford Wellcome Centre for Tropical and Infectious Diseases wrote ("Evidence of Blood-Brain Barrier Dysfunction in Human Cerebral Malaria," Neuropathol Appl Neurobiol, August 1999;25(4):331-340).

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Source: Blood Weekly (1999-09-27)

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