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Pathogenesis

Protein Coagulation Associated with Neurodegenerative Pathologies

Published in Blood Weekly, October 11th, 1999

Interacting processes in protein coagulation are related to pathologies in several diseases, a recent study shows.

"A strong interest is currently focused on protein self-association and deposit," wrote P.L. Sanbiagio and colleagues from the University of Palermo, Italy. "This usually involves conformational changes of the entire protein or of a fragment. It can occur even at low concentrations and is responsible for pathologies such as systemic amyloidosis, Alzheimer's and Prion diseases, and other neurodegenerative pathologies."

The researchers reported on experiments using bovine serum albumin in which they studied proteins responsible for...

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