Published in Blood Weekly, November 1st, 1999
Apoptosis plays an important role in cellular homeostasis, including that of T cells, noted W. Tu, University of Hong Kong, and colleagues.
Previously, Tu et al. showed that insulin-like growth factor 1 (IGF-1) could promote the maturation of neonatal T cells and regulate cord blood naive T-cell differentiation towards Th1 profile. Although IGF-1 has been reported to have an anti-apoptotic effect effect on murine hemopoietic cells, little is understood about its anti-apoptotic roles in T cells.
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