Bioartificial Blood Vessels

Technique Uses Body To Engineer New Blood Vessels

Published in Blood Weekly, November 8th, 1999

Researchers at Organogenesis, Inc., Massachusetts, have put a twist on blood vessel engineering.

Reported in the October 1999 issue of Nature Biotechnology, the technique devised by Dr. Susan Sullivan, Organogenesis, and colleagues allows vascular cells to grow in situ on a collagen infrastructure of synthetic vessels. The body does the tissue engineering.

"They constructed the synthetic vessels by forming a tube of collagen (extracted from the pig small intestine), adding another thin inner layer of cow collagen, cementing the resulting two-layer tube together with a crosslinking agent, and coating the inner surface with heparin anticoagulant,"...

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Source: Blood Weekly (1999-11-08)

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