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Stem Cell Transplantation

Tiered HLA Typing Strategy Is Efficient, Cost-Effective

Published in Blood Weekly, November 15th, 1999

Tiered human leukocyte antigen (HLA) typing strategies can work well when typing cases that involve sibling donors, according to a recent conference report.

Historically, HLA typing for stem cell transplantation involved the use of serologic methods for class I antigen assignment. More recently, molecular methods have been used for class II characterization.

Serologic typing requires significantly more sample and can be less accurate than molecular typing. For these reasons, E.A. Trachtenberg and colleagues, Children's Hospital Research Institute, Oakland, California, developed a highly efficient HLA class I and II typing strategy that uses...

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