Megakaryocyte Differentiation
Regions of Glycoprotein V Gene Promoter Are Defined
Published in Blood Weekly, November 29th, 1999
Glycoprotein V (GPV) is a subunit of the platelet GPIb-V-IX receptor for von Willebrand factor thrombin. GPV is particularly found in platelets and mature megakaryocytes. Thus, studies of the GPV gene can provide insight into mechanisms that govern megakaryocyte differentiation, noted Adeline Lepage and colleagues.
Lepage et al. isolated the human GPV promoter and, using systematic DNase I protection and reporter deletion assays, localized elements important for the promoter's tissue-specific transcriptional activity...
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Source: Blood Weekly (1999-11-29)
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