Hypercoagulation (Therapy)

Compound 48/80 May Provide Relief under Septic Conditions

Published in Blood Weekly, February 10th, 2000

A compound may provide therapy for instantaneous relief of hypercoagulation under septic conditions, according to a report from the United States.

Hypercoagulability is a commonly exhibited endotoxemia septic symptoms which can contribute to the manifestation of disseminated intravascular coagulation presenting threats to cardiovascular functions. The underlying mechanism, however, remains largely complex and unknown, noted A. J. Chu and colleagues.

Chu et al. herein determined whether bacterial endotoxin (LPS) upregulates the activities of clotting factors in plasma, contributing to extrinsic hypercoagulation ("Compound 48/80 suppresses monocytic...

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Source: Blood Weekly (2000-02-10)

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