Neuroblastoma

Method Purges Neuroblastoma Cells from Autologous Stem Cells

Published in Blood Weekly, February 24th, 2000

Researchers in the United States are working on a method to preserve survival of human hematopoietic progenitor cells while purging these cells of neuroblastoma contaminated cells.

Children with stage III or IV neuroblastoma (NB) commonly are treated with surgery, chemotherapy, and stem cell rescue. Gene marking studies have demonstrated that reinfusion of autologous stem cells contaminated with a level of tumor cells that is undetectable morphologically contributes to relapse, Meck and colleagues noted.

Meck et al. reported that they are developing a method to eliminate NB cells from stem cell preparations. They presented their research at the...

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Source: Blood Weekly (2000-02-24)

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