Kappa Proteins

Influence on Phenotype and Behavior of Cells Studied

Published in Blood Weekly, March 9th, 2000

The nuclear factor-kappa B (NF-kappa B) gene transactivator may influence the phenotype and behavior of cells exposed to less intensive photodynamic therapy (PDT) regimens, according to researchers at QLT PhotoTherapeutics Inc.

NF-kappa B serves in the formation of immune, inflammatory, and stress responses, and, in quiescent cells, it principally resides within the cytoplasm in association with inhibitory kappa (I kappa B) proteins.

D.J. Granville and colleagues evaluated the status of I kappa B and NF-kappa B proteins for promyelocytic leukemia HL-60 cells treated at different intensities of PDT ("Nuclear factor-kappa B activation by the...

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Source: Blood Weekly (2000-03-09)

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