Published in Blood Weekly, March 16th, 2000
Because TPO and c-mpl support the proliferation of multiple types of immature hematopoietic progenitor cells and induce clonal growth of leukemic cells, K. Kaban and colleagues investigated whether overexpression of (TPO) or c-mpl might correlate with progression of CML, disease aggressiveness, or response to therapy ("Expression of thrombopoietin and its receptor (C-mpl) in chronic myelogenous leukemia - Correlation with disease progression and response to therapy," Cancer, 2000;88(3):570-576).
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