Microcirculatory Thrombosis

Mechanism of Cell Injury Is Multi-Faceted

Published in Blood Weekly, March 16th, 2000

The abnormal cleavage of the vWF subunit, with formation of different multimers with increased platelet aggregating capacity is one important mechanism to increase the microcirculatory thrombosis, according to a researcher in Argentina.

In thrombotic thrombocytopenic purpura (TTP) and in hemolytic uremic syndrome (HUS) fibrin-platelet thrombi occlude arterioles and capillaries. The mechanism of endothelial cell injury and the mechanism of thrombosis are the most important physiopathological events in this pathology and are largely unknown, noted J.C.S. Avalos ("Microangiopathies: HUS/TPP. Physiopathologic aspects" Medicina - Buenos Aires,...

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Source: Blood Weekly (2000-03-16)

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