Lymphocyte Gene Therapy

Adeno-Associated Virus Vectors Useful Against Lymphocyte Targets

Published in Blood Weekly, March 23rd, 2000

Adeno-associated virus vectors appear to be useful for lymphocyte gene therapy, a study from Japan's Nippon Medical School suggests.

Researcher Noriko Suzuki and colleagues reported their findings at the conference, "Gene Therapy of Cancer VII," held in San Diego, California.

Peripheral blood lymphocytes are important target cells for gene therapy of various disorders, including neoplastic diseases. However, lymphocytes are quite resistant to transduction with currently used viral vectors such as amphotropic retroviral vectors and adenoviral vectors.

In recent studies, Suzuki et al. showed that HIV vectors pseudotyped with HIV...

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Source: Blood Weekly (2000-03-23)

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