Published in Blood Weekly, March 23rd, 2000
These cells, which are found in the bone marrow and blood, are capable of developing into any kind of blood cell. The discovery of this molecular switch, a protein called p21, may solve a major limitation to the use of these stem cells - the fact that naturally they occur in very small numbers and rarely reproduce.
"Hematopoietic stem cells tend to be very rare and quiescent [inactive]," says David Scadden, MD, of the MGH Cancer Center and the MGH AIDS Research Center,...
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