Septic Shock

Macrophage Migration Inhibitory Factor Mediates Sepsis

Published in Blood Weekly, March 30th, 2000

Macrophage migration inhibitory factor (MIF) seems to play a major role in the pathogenesis of sepsis and septic shock, according to a recent study.

"Identification of new therapeutic targets for the management of septic shock remains imperative as all investigational therapies, including anti-tumor necrosis factor (TNF) and anti-interleukin (IL)-1 agents, have uniformly failed to lower the mortality of critically ill patients with severe sepsis," reported T. Calandra and colleagues in Switzerland ("Protection from septic shock by neutralization of macrophage migration inhibitory factor," Nature Medicine, February 2000;6(2):164-170).

Calandra...

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Source: Blood Weekly (2000-03-30)

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