Cell Biology

Homocysteine May Stimulate Calcium Release in Vascular Smooth Muscle Cells

Published in Blood Weekly, May 4th, 2000

Researchers at the University of Mississippi have found that homocysteine appears to cause the release of Ca²⁺ in vascular smooth muscle cells (VSMC).

Though is it known that homocysteine in the plasma of coronary heart disease patients causes the propagation of VSMC and elevates deposits of extracellular matrix (ECM) components, it is unclear exactly how homocysteine causes these effects or what role it plays in vascular disease, according to researchers.

V.S. Mujumdar and colleagues investigated whether homocysteine might stimulate the production of ECM by causing calcium to be produced within the VSMC ("Homocysteine induces calcium...

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Source: Blood Weekly (2000-05-04)

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