Published in Blood Weekly, May 4th, 2000
"Relative quiescence is a defining characteristic of hematopoietic stem cells, while their progeny have dramatic proliferative ability and inexorably move toward terminal differentiation," explained D.T. Scadden and colleagues at Harvard University ("Hematopoietic stem cell quiescence maintained by p21(Cip1/waf1)," Science, 2000;287(5459):1804-1808).
Scadden et al. tested the conjecture that hematopoietic stem cell quiescence is necessary to prevent premature depletion using mice...
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