Vector Development
Serum Inhibition of Polycationic Transfer Overcome by Ca2+ Ions
Published in Blood Weekly, May 18th, 2000
"One of the drawbacks of polycationic and cationic liposomal gene transfer is its sensitivity to serum," noted A. Haberland and colleagues, Max Delbruck Center for Molecular Medicine, Franz Volhard Clinic, Germany. "Gene therapy requires the transfectant-DNA complex to be resistant to serum as well as blood. Since Ca2+ has proved to be an efficient cofactor of polycationic gene transfer, we decided to investigate its effects on transfection in the presence of serum."
Haberland et al. published their study in the...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Blood Weekly
Source: Blood Weekly (2000-05-18)
More Articles from Blood Weekly
- Blood Banking
Red Blood Cell Modulation Decreases During Storage - Autotransfusion Technology
New System Evaluated - Blood Safety
White Blood Cell Filtration Can Reduce Transmission of Rickettsial Disease - Bone Marrow Transplantation
Mycophenolate Mofetil Can Prevent Acute Graft-Versus-Host Disease in HLA-Mismatched Recipients - Graft-vs.-Host Disease
First Report of Causation By White Blood-Cell-Reduced Red Blood Cell Infusions - Stroke
Anticoagulation Agent Has Favorable Effect for Treating Acute Stroke - More from this issue of Blood Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
