Huntington's Disease

Manipulated Stem Cells Useful for Brain Repair

Published in Blood Weekly, June 8th, 2000

Researchers recently reported that central nervous system stem cell expansion is a source of gabergic neurons which can be used for brain repair.

"We asked whether 1) multi-fold expanded striatal stem cells can give rise to mature neuronal phenotypes, 2) whether neuronal differentiation can be modulated by extrinsic factors, 3) whether stem-cell derived neurons are functional in vitro and upon transplantation into a rat model of Huntington's disease," reported Viviane Tabar, MD, and colleagues.

Using cells from the rat E14 LGE, researchers caused a 1,500-fold increase in cell number through proliferation in serum-free medium and bFGF. A majority of...

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Source: Blood Weekly (2000-06-08)

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