Prothrombosis

Effects of Two Human Monoclonal IgG Antiphospholipid Antibodies Analyzed

Published in Blood Weekly, June 15th, 2000

Researchers in Germany analyzed the prothrombotic effects of two human monoclonal immunoglobulin G (IgG) antiphospholipid antibodies that had similar specificity.

"Two human monoclonal antiphospholipid antibodies (APA) of the IgG type, HL-SB and RR-7F have been generated from a patient with primary antiphospholipid syndrome and recurrent cerebral microemboli (HL) and from a patient with SLE without evidence of recurrent thrombosis (RR)," stated K.J. Lackner and colleagues, University of Regensburg, Germany. "Both monoclonal APA have similar characteristics in ELISA tests. To further analyze the prothrombotic potential, their effect on human monocytes and platelets,...

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Source: Blood Weekly (2000-06-15)

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