Published in Blood Weekly, June 29th, 2000
"Lethal HVG syndrome is the rapidly progressive disease that follows the perinatal inoculation of semiallogeneic donor spleen cells into susceptible strains of mice," said R.C. Hard and colleagues from the Medical College of Virginia. "RFM/(T6xRFM)F1 chimeras are dead in 30 days with lymphosplenomegaly, nephropathic immune complexes, and excessive serum levels of IgG1 [immunoglobulin G1] and IgE. The aim of this study was to modulate the effects of the allogeneic HVG reaction on B cells...
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