Diagnostics

Variability in Hepatitis B Viral Loop Region Affects Assay in Carriers

Published in Blood Weekly, June 29th, 2000

by Sonia Nichols, Staff Medical Writer -- Hepatitis B surface antigen (HBsAg) cannot be detected in some people who carry the virus because of variability in the some parts of their virus, according to a study recently published in the Journal of General Virology.

Most carriers display HBsAg in their sera, which can indicate the level of infection present, said K.M. Weinberger et al. of the University of Regensburg in Germany. "In some individuals, however, this antigen cannot be detected by routine serological assays despite the presence of virus in liver and peripheral blood," the researchers said.

To study why this probably occurs,...

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Source: Blood Weekly (2000-06-29)

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