Published in Blood Weekly, July 13th, 2000
"Platelet adhesion in arterial blood flow is mainly supported by the platelet receptor glycoprotein (GP) Ib, which interacts with von Willebrand's factor (vWF) that is bound to collagen at the site of vessel wall injury," stated N. Cauwenberghs and colleagues, Katholieke University Leuven, Belgium. "Antibody 6B4 is a monoclonal antibody raised against purified human GPIb. MAb 6B4 inhibits both ristocetin- and botrocetin-induced, vWF-dependent human platelet agglutination. MAb 6B4 furthermore blocks shear-induced adhesion of human platelets to...
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