Stem Cell Transplantation

Antibody Therapy/Sublethal Myeloablative Conditioning Induces Allograft Tolerance

Published in Blood Weekly, July 27th, 2000

Anti-CD154 monoclonal antibody (MAb) therapy combined with sublethal myeloablative conditioning induces allograft tolerance in a murine model, according to a recent study.

"Induction of allogeneic hematopoietic chimerism using sublethal myeloablative conditioning in the absence of graft-vs-host disease (GVHD) is a major goal of stem cell transplantation," reported D.S. Forman and colleagues from the University of Massachusetts Medical School. "We have achieved stable hematopoietic chimerism using BALB/c (H2^d) mice given C57BL/6 (H2^b) bone marrow cells, low dose irradiation, and a brief course of anti-CD154 MAb to block CD40-CD154...

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Source: Blood Weekly (2000-07-27)

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