Organ Rejection

Drug Combination Reduces Occurrence of Kidney Transplant Rejection

Published in Blood Weekly, July 27th, 2000

Despite the use of multidrug immunosuppressive regimens, acute rejections episodes are still an important clinical challenge after renal transplantation. These events arise in 20%-40% of patients, and are a risk factor for chronic graft failure.

In the July 14 issue of the Lancet, The Rapamune U.S. Study Group reported the findings of their study that compared two drug combinations to test their effectiveness in reducing the rate of renal graft (allograft) rejections.

Sirolimus has provided potent immunosuppression in laboratory experiments and powerful protection against rejection episodes when combined with the drug cyclosporin in human...

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Source: Blood Weekly (2000-07-27)

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