Hemophilia

Premature Depletion of Factor XIII May be Cardioprotective

Published in Blood Weekly, September 7th, 2000

The premature depletion of the factor XIII activation peptide segment has cardioprotective effects, a new study has found.

"In the blood coagulation cascade, thrombin cleaves fibrinopeptides A and B from fibrinogen revealing sites for fibrin polymerization that lead to insoluble clot formation," stated T.A. Trumbo and colleagues, University of Louisville, Kentucky. "Factor XIII stabilizes this clot by catalyzing the formation of intermolecular cross-links in the fibrin network. Thrombin activates the Factor XIII a(2) dimer by cleaving the Factor XIII activation peptide segment at the Arg(37)-Gly(38) peptide bond."

The researchers used a high...

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Source: Blood Weekly (2000-09-07)

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