Hemodialysis

Treatment Activates Coagulation Factors

Published in Blood Weekly, September 21st, 2000

Supplemental anticoagulant factors may be necessary to prevent blood clotting in patients undergoing hemodialysis, suggest researchers in The Netherlands.

"Generation of factor XII, thrombin antithrombin complexes, prothrombin fragment 1+2, and thrombus precursor protein has been monitored in 16 subjects during hemodialysis," reported P.C.M. Bartels and colleagues, Medical Center Alkmaar. "Immediately after starting treatment, contact of blood with the negatively charged surfaces of the polyacrylnitril membrane AN-69 resulted in a 9%-45% decrease in factor XII activity."

The researchers observed peak concentrations for thrombin antithrombin...

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Source: Blood Weekly (2000-09-21)

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