Transplant Rejection

Mechanism Found Behind Drug-Free Acceptance of New Organs

Published in Blood Weekly, September 28th, 2000

Scientists at Ohio State University may have discovered how a few rare organ transplant recipients manage to prevent their bodies from rejecting their new organs without the help of drugs.

In this unusual category of patients, who retain healthy function of their transplants even when they go off immunosuppressive drugs, the immune system still reacts normally. However, the system essentially counteracts its own normal combative response against the donor organ, researchers found.

"It's like two negatives making a positive," said Anne M. VanBuskirk, research scientist at Ohio State's department of surgery and lead author of the study. VanBuskirk...

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Source: Blood Weekly (2000-09-28)

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