Blood Products

Coagulation Factor XI Found in Intravenous Immunoglobulin Preparations

Published in Blood Weekly, October 5th, 2000

The contamination of intravenous immunoglobulin (IVIG) with coagulation factor XI may be responsible for thrombosis events in patients receiving IVIG therapy, say researchers in the United States.

"A small number of thromboembolic events, including deep venous thrombosis and myocardial infarction, have been reported in patients receiving IVIG," stated A.S. Wolberg and colleagues, Durham Veterans Administration Medical Center, North Carolina. "These events have primarily occurred in patients receiving high-dose IVIG and have been attributed to an increase in blood viscosity.

"To test the hypothesis that a procoagulant might be present in IgG...

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Source: Blood Weekly (2000-10-05)

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