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HIV Gene Therapy

Antisense Enables Long-Term Survival of Transduced Immune Cells

Published in Blood Weekly, October 19th, 2000

Long-term survival of therapeutic gene transduced CD34+ cells in peripheral blood stem cell (PBSC) was realized in a study involving HIV-1 infected patients.

D. Liu and colleagues from Enzo Therapeutics, Inc., New York, and the University of California tried "to restore immunocompetency in HIV-1 infected individuals by establishing a sustained population of peripheral blood mononuclear cells (PBMC) expressing anti-HIV-1 antisense RNA and resistant to HIV-1 infection."

D. Engelhardt, Enzo Therapeutics, presented data from the study at the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), held September 17-20,...

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