Organ Rejection

Presence of Blood Components Indicate Risk

Published in Blood Weekly, December 7th, 2000

Two tiny substances in the blood might alert physicians to which heart transplant patients are likely to experience some form of organ rejection, a Johns Hopkins University study indicates.

Researchers collected 132 blood specimens and heart tissue samples from 35 patients between February 1997 and May 1998. The higher the level of the substances prothrombin fragment (PF) 1.2 and p-selectin, substances circulating in the blood that are involved in clotting, the higher the rate of rejection, researchers found. Low levels of both substances predicted that the specimen would be free of rejection 88% of the time.

In addition, patients with a p-selectin...

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Source: Blood Weekly (2000-12-07)

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