Cord Blood

Understanding Developmental Changes Necessary for Future Use

Published in Blood Weekly, February 1st, 2001

According to a study from England, umbilical cord blood CD34⁺ hematopoietic progenitor and stem cells go through developmental changes in adhesion molecule expression during different stages of gestation.

"The purpose of this study was to determine whether expressions of the cell adhesion molecules LFA-1 (CD11a), VLA-4 (CD49d), and L-selectin (CD62L) on CD34⁺ stem and progenitor cells in umbilical cord blood change during gestation," stated D.V. Surbek and colleagues, University of London King's College, England. "In a prospective observational study, three-color fluorescence-activated cell sorting was used to assess the levels of expression of...

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Source: Blood Weekly (2001-02-01)

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