Stem Cells

Neutrophil Respiratory Burst Not Crucial for Migration

Published in Blood Weekly, February 15th, 2001

- by Michael Greer, staff medical writer -- Contrary to conventional wisdom, stem cells do not seem to require neutrophil signals to trigger their migration from bone marrow, according to hematologists working in The Netherlands.

"It has been suggested that mature neutrophils may play an essential role in the cascade of events leading to egress of stem cells from the bone marrow to the peripheral blood," R. Vanos and colleagues at Leiden University wrote in the British Journal of Haematology.

To investigate this possibility, Vanos et al. compared the process of stem cell mobilization in healthy mice and mice with chronic granulomatous disease...

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Source: Blood Weekly (2001-02-15)

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