Anemia

Mitochondrial Dysfunction Implicated in Blood Cell Apoptosis

Published in Blood Weekly, February 15th, 2001

- by Michael Greer, staff medical writer -- Hematologists in Switzerland have presented evidence showing that dysfunctional mitochondria are at least partly responsible for the suicide of red blood cell precursors observed in patients with idiopathic acquired sideroblastic anemias (IASAs).

"Idiopathic acquired sideroblastic anemias are characterized by mitochondrial iron accumulation, bone marrow erythroid hyperplasia, and decreased peripheral red blood cell counts," T.W. Matthes and colleagues at the University of Geneva explained in the British Journal of Haematology. "Increased intramedullary apoptosis of erythroid precursors is presumed to [underlie]...this...

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Source: Blood Weekly (2001-02-15)

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