Hodgkin's Lymphoma

Interleukin-10 Levels Can Predict Outcome

Published in Blood Weekly, March 22nd, 2001

by Michael Greer, staff medical writer -- Levels of the cytokine interleukin-10 (IL-10) are independent predictors of outcome for patients with Hodgkin's lymphoma, according to researchers in Greece.

Because one function of IL-10 is to protect cells from apoptosis induced by steroids or doxorubicin, and malignant Hodgkin cells have IL-10 receptors, Theodoros P. Vassilakopoulos and colleagues suspected that the cytokine may have a protective effect on these cancerous cells.

After studying more than 120 Hodgkin's patients who had been "treated with ABVD or equivalent regimens with or without radiotherapy," they appear to have to been proved correct. ...

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Source: Blood Weekly (2001-03-22)

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