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Breast Cancer

Intensified Chemotherapy/Stem Cell Treatment May Not Improve Survival

Published in Blood Weekly, March 29th, 2001

by Michael Greer, staff medical writer - Early intensification of high-dose chemotherapy (HDCT) with stem cell support seems to have little impact on metastatic breast cancer.

Although many researchers suspect that early dose intensification should produce better results than late intensification, the reports from "randomized trials comparing standard- and high-dose chemotherapy with ASCT [autologous stem cell transplantation] are still controversial," according to Andreas Schneeweiss and colleagues.

Despite improving initial complete remission (CR) rates, Schneeweiss et al. found that double- and triple-dose HDCT (D- and T-HDCT) had no significant...

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