Acute Myeloid Leukemia

Progression From Myeloproliferative Disease To AML Studied

Published in Blood Weekly, April 5th, 2001

by Deborah W. Heinrich, staff medical writer - Researchers are using chimeric mice to study the mechanisms that cause myeloproliferative disease (MPD) and acute myeloid leukemia (AML).

"Mice transplanted with bone marrow cells expressing NUP98-HOXA49 through retroviral transduction acquire a myeloproliferative disease (MPD) and eventually succumb to acute myeloid leukemia (AML)," reported E. Kroon et al. ("NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice," EMBO Journal, 2001;20(3):350-361.)

Bone marrow cells expressing HOXA49 (a gene found at a breakpoint for chromosomal translocations...

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Source: Blood Weekly (2001-04-05)

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