Connective Tissue Disease

Telomerase Activity In Peripheral Blood Mononuclear Cells Linked To Severity

Published in Blood Weekly, April 12th, 2001

by Michael Greer, staff medical writer - Telomerase activity in peripheral blood mononuclear cells (PBMCs) is linked to the presence and severity of systemic connective tissue diseases such as lupus and Sjogren's syndrome, a new study reports.

"Telomerase activity has been detected in a large number of cancers, as well as human germline tissue, but is absent in most normal somatic tissue," Y. Katayama and colleagues wrote in the Journal of Rheumatology. "It has been reported that telomerase is also expressed at a low level in normal peripheral blood lymphocytes and that its activity is increased by antigen processing."

Katayama et al....

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Source: Blood Weekly (2001-04-12)

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