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Transfusion Medicine

Leukocyte Depletion Not Linked To Colorectal Cancer Recurrence, Reduced Survival

Published in Blood Weekly, April 19th, 2001

by Michael Greer, staff medical writer - Using leukocyte-depleted blood for colorectal cancer surgery transfusions has little effect on the associated risks, hematologists in The Netherlands report.

"Perioperative blood transfusions are reported to be related to cancer recurrence and reduced survival," explained L.M.G. Van de Watering and colleagues at Leiden University. "Different underlying mechanisms have been proposed, and allogeneic leukocytes in transfused blood have been suggested to contribute to this phenomenon."

However, Van de Watering et al. did not find that leukocyte depletion affected mortality or relapse rates. In fact, despite...

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