Sickle Cell Disease

Researchers Test "Mini" Bone Marrow Transplant Treatment In Mice

Published in Blood Weekly, May 17th, 2001

Treatments for sickle cell anemia, such as blood transfusions and total marrow transplants, sometimes have toxic side effects. In developing a safer, lasting treatment, Johns Hopkins Children's Center researchers are testing a new bone marrow transplant method in mice.

A group led by pediatric hematologists Robert Iannone, MD, and James Casella, MD, and oncologist Ephraim Fuchs, MD, found that a "mini-transplant" of just 40% normal bone marrow in the rodents was enough to reduce anemia and life-threatening organ injury, the most damaging symptoms of sickle cell anemia (SCA).

A genetic blood disease, SCA disproportionately affects Americans of...

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Source: Blood Weekly (2001-05-17)

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