Myocardial Infarction

Tissue Factor Regulates Monocyte Coagulant Activity

Published in Blood Weekly, June 21st, 2001

by Michael Greer, senior medical writer - An elevation in tissue factor (TF) levels during heart attacks increases monocyte-triggered coagulation, providing a possible therapeutic target to halt this detrimental coagulation increase.

"In acute myocardial infarction (AMI), monocyte procoagulant activity is increased and may contribute to the risk for recurrence and other thrombotic events," explained Ilka Ott and colleagues at the Munchen University of Technology, Germany.

Rises in TF RNA shortly after AMI, without accompanying increases in substances that inhibit TF, was linked to elevated procoagulant activity by Ott and coworkers.

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Source: Blood Weekly (2001-06-21)

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