Thromboembolism

Amniotic Fluid Leakage Can Increase Risk

Published in Blood Weekly, June 28th, 2001

by Michael Greer, senior medical writer - Amniotic fluid leakage into the bloodstream may provoke dangerous coagulation in pregnant women, researchers in Poland warn.

"Tissue factor (TF) is known to be present in a high concentration in amniotic fluid," explained M. Uszynski and colleagues at Ludwik Rydygier Medical University. TF promotes blood clotting, and its activity is normally offset by that of tissue factor pathway inhibitor (TFPI).

However, Uszynski and coworkers found that amniotic TFPI may not be able to prevent the procoagulatory effects of TF when amniotic fluid finds its way into the maternal bloodstream.

The...

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Source: Blood Weekly (2001-06-28)

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