Animal Models

Murine Strain Differences Affect Toxic Hematologic Responses

Published in Blood Weekly, June 28th, 2001

by Michael Greer, senior medical writer - Genetic variations between strains of research mice can significantly affect the results of toxicology studies, researchers in England report.

"Much toxicological research continues to be done using genetically undefined 'outbred' stocks of mice and rats, although the case for using isogenic strains has been made repeatedly in the literature over a period of more than two decades," wrote M.F.W. Festing and colleagues at the University of Leicester.

Festing and coworkers showed that toxicology tests using purebred mice can reveal more potential hazards of a potent drug than can testing with multiple strains...

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Source: Blood Weekly (2001-06-28)

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