Leukemia

Metabolic Changes May Underlie Multidrug Resistance

Published in Blood Weekly, August 9th, 2001

by Michael Greer, senior medical writer - Altered cellular metabolism may mediate the antitumor drug resistance seen in some leukemia cell lines, researchers in Sweden say.

"Cross-resistance between different classes of antineoplastic agents can jeopardize successful combination cancer chemotherapy," according to Kourosh Lotfi and colleagues at the Faculty of Health Sciences in Linkoping and other institutions.

After examining malignant cells refractory to several of the most commonly used anticancer drugs, Lotfi and coworkers found that these cells had higher levels of enzymes that deactivate nucleotides and decreased levels of DNA-splicing...

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Source: Blood Weekly (2001-08-09)

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