AIDS Therapies

Indinavir Inhibits Lymphocyte Cell Cycle, But Not Apoptosis

Published in Blood Weekly, September 13th, 2001

by Michael Greer, senior medical writer - Contrary to some reports, researchers in the United States say that the protease inhibitor indinavir does not prevent programmed cell death of white blood cells.

"Indinavir (IDV) is a potent and selective human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI) widely used in antiretroviral therapy for suppression of HIV, but its effects on the immune system are relatively unknown," explained Savita Pahwa and colleagues at New York University. "Recently, it has been reported that PIs inhibit lymphocyte apoptosis."

Although indinavir and other protease inhibitors may extend the lifespan of...

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Source: Blood Weekly (2001-09-13)

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