Published in Blood Weekly, October 18th, 2001
The finding adds significantly to the understanding of how the disease might be treated and to the general knowledge of the molecules involved in blood clotting.
In TTP patients, clumps of red blood cells and a large protein called von Willebrand factor (VWF) gather in the small blood vessels of many organs, including the brain and kidneys. Normally VWF mediates the interactions among platelets and between them and the walls of blood vessels, maintaining the balance between bleeding and clotting.
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