Stem Cell Transplantation

Pegylated Megakaryocyte Growth Factor Effective For Mobilization

Published in Blood Weekly, November 8th, 2001

by Michael Greer, senior medical writer - Pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) shows promise for use in mobilizing stem cells for harvesting, according to researchers in Japan.

Dr. K. Honda and colleagues at Okayama University Medical School evaluated the efficacy of PEG-rHuMGDF for mobilizing peripheral blood progenitor cells (PBPCs) in a murine model.

This growth factor produced effective PBPC mobilization, either alone or in combination with recombinant human granulocyte colony-stimulating factor (rhG-CSF), Honda and coauthors found.

Mice treated with PEG-rHuMGDF displayed higher...

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Source: Blood Weekly (2001-11-08)

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