Cord Blood Transplantation

Interleukins May Reduce Graft-Versus-Host Risk

Published in Blood Weekly, November 8th, 2001

by Michael Greer, senior medical writer - Several interleukins may be useful for preventing graft-versus-host disease in patients undergoing cord blood transplantation, according to researchers in Taiwan.

"Decreased graft-versus-host disease (GvHD) in cord blood (CB) transplantation may be attributed to the immunological immaturity and susceptibility to apoptosis of CB mononuclear cells (MNCs)," explained Dr. Kuo Ming-ling and colleagues at Chang Gung Children's Hospital in Taoyuan.

Interleukin (IL)-12 and IL-15 can make cord blood MNCs even more susceptible to apoptosis, and may further reduce GvHD risk in transplant recipients, Kuo and coauthors...

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Source: Blood Weekly (2001-11-08)

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