Mycobacteria

Tuberculosis-Infected Blood Cells Upregulate Cell Cycle Proteins

Published in Blood Weekly, November 15th, 2001

by Michael Greer, senior medical writer - Human monocytes infected with Mycobacteria tuberculosis display elevated expression of proteins that help regulate the cell cycle in damaged cells, researchers in Italy report.

F. Galietti and colleagues at the University of Turin's San Luigi Gonzaga Hospital in Orbassano conducted a study to "evaluate the expression of such proteins in peripheral blood human monocyte cultures infected with strains of different mycobacterial pathogens."

Unlike less-pathogenic mycobacteria, M. tuberculosis induces a significant upregulation of p53 and p21 in blood cells, they found.

The...

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Source: Blood Weekly (2001-11-15)

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